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Cell adhesion molecule CD146 and skin cancer

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Cell adhesion is the process by which the cells are interacting and attaching to their surrounding environment. This process is achieved through the interaction of a family of proteins called cell adhesion molecules (CAM). In physiological conditions, this phenomenon is implicated in organ structures, cell-cell communication, immune cell migration. However, in pathological conditions like cancer, these pathways are implied in tumor propagation, interaction with the microenvironment  and metastasis.(1)

CD146 or melanoma cell adhesion molecule (MCAM) is a member of the immunoglobulin superfamily. CD146 is mostly only expressed in embryonic tissue under physiological condition. Its overexpression has been associated with malignant melanoma and  carcinoma. In addition to its role in diagnostic, it has been considered over the past years as a promising target for cancer immunotherapy. (2-3-4)

The anti-CD146 (MM-0302) from the CCAB series can be used to study the expression of CD146 in flow cytometry. Prevention, by reduction of UV exposure, use of protective clothes and sunscreen application, remains the best option to fight skin cancer incidence in the population. (5)