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DDRs, a family of 2 proteins, are key in cell-to-microenvironment communication

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     The cellular microenvironment can modulate intracellular pathways, these interactions can occur in normal or physiopathological conditions. However, if pro-survival molecules present in the microenvironment can be beneficial to normal cells, it would also be the case for neoplastic cells.(1) Tumor microenvironment (TME) interactions have been studied and targeted in the past decade to understand how extracellular components can affect intracellular pathways. DDR1 and 2 (or CD167a and b) are receptor tyrosine kinases (RTKs) that are known to interact with collagen (one of the major components of the extracellular matrix).(2) DDRs are often overexpressed in cancer and, moreover, some inhibitors are presently evaluated in clinical trials.(3) An antibody panel has been developed for the MédiMabs-CCAB series to recognize specifically CD167a/DDR1 (MM-0304) and CD167b/DDR2 (MM-0305) and we hope it would help you in your research projects.