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RPTP and synaptogenesis

Receptor protein tyrosine phosphatases (RPTPs) are protein family with implications in neuron development and axonal growth.  RPTPs implications in synaptogenesis, through the formation of trans-synaptic adhesion complexes, have been studied over the past decades. (1) The ability to control this process would be a key element for the development of neuro-regenerative therapy. (2) The type IIa RPTP named RPTPsigma is highly expressed in the developing and adult brain of mammals. (3-4) RPTPsigma role in adult brain has been demonstrated to be one inhibition of axon regeneration and control of axon growth. (5) Antibodies specific to RPTPsigma have also shown a promising potential to regulates its function. (6) Similar strategies could be developed has a key element of axonal regenerative therapy. Whether you are interested to study RPTPsigma with our MM-0020-P antibody or you want to develop new antibodies for your project, MédiMabs will be pleased to assist you.