When one and one make two. Dimerization is an important process in biology and especially in signal transduction. Receptor tyrosine kinases (RTKs) are good examples to illustrate this process. In general, the binding of the ligand to its specific pair of molecules will cause the dimerization of the molecule or the stabilization of the dimer. Once stabilized, the signal will be transmitted through the cell membrane by trans-phosphorylation of different members of the pair. This will generate binding sites for cytoplasmic proteins that will then be able to relay signals inside the cell. A simple but complex process that ensure and mediate cell signaling in physiological conditions. EGFRs, DDRs and FGFRs are classic examples of these types of receptors and can be studied using our different set of antibodies from the CCAB series.
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