The exhumation of a possible treatment against the “brain-eating” Alzheimer’s disease

The epithelial cell phenotype is defined by a cell organization that are structured in a single layer also called cell sheet. Typical epithelial cells have basal and apical polarity. On the other hand, the mesenchymal phenotype is associated with motility and invasiveness. In a physiological context, these phenotypes are intrinsic of these cell functions, for example the intestinal mucosa and his cell wall that mediates the entrance of nutrients in the bloodstream or the immune cells that migrate to the foci of infection.

Four years ago, two different research teams have highlighted the possibility that the composition of the gut microbiota could modulate the efficacy of the cancer immunotherapy based on immune checkpoint inhibitors PD-L1 (1) and CTLA-4 (2).

 Prostate cancer is the 3rd lethal type of cancer in the United States. Its diagnostic and stage assessment is done by histological analysis of microbiopsy, imagery, and serum marker evaluation. (1)