MM-0200-P

GluR2-phospho S880 Mouse Monoclonal Antibody (Glu2-p 880)

Application :

ELISA, IP, WB

Reactivity :

Rat

Host :

Mouse

Clonality :

Monoclonal

Out of stock

Overview

Target

GluR2-phospho S880

Target background

In the nervous system, much of the fast-excitatory transmission is sent by AMPA receptors, tetrameric ionotropic receptors that may be composed of four types of glutamate receptor subunits, formerly known as GluR1-4, and now often abbreviated as GluA1-4. The composition of receptor subunits determines the trafficking of the AMPA receptor in and out of the synapse, which can in turn cause changes in synaptic plasticity, including regulation of long term potentiation (LTP) and long term depression (LTD). Phosphorylation of GluA2 at serine 880 has been shown to disrupt interactions with the glutamate receptor interacting protein (GRIP), thus regulating receptor stability at the synapse.

Target alias

GluR2, GluA2

Immunogen

Peptide around phospho-serine 880

Specificity

The antibody recognizes the Glutamate Receptor 2-phosphoserine-880.

Clone ID

Glu2-p 880

Isotype

IgG

Preservative

None

Format

Lyophilized protein G purified in PBS pH7.4

Recommend starting dilution

If reconstituted with deionized water in 100 µl: WB 1:500-1:1000; ELISA 1:5000. Optimal dilution has to be determined by the user.

Limitations

Research Use Only

Storage

Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Product datasheet

GluR2-phospho S880 Mouse Monoclonal Antibody (Glu2-p 880)

SKU: MM-0200-P
100 µg

Overview

Target

GluR2-phospho S880

Target background

In the nervous system, much of the fast-excitatory transmission is sent by AMPA receptors, tetrameric ionotropic receptors that may be composed of four types of glutamate receptor subunits, formerly known as GluR1-4, and now often abbreviated as GluA1-4. The composition of receptor subunits determines the trafficking of the AMPA receptor in and out of the synapse, which can in turn cause changes in synaptic plasticity, including regulation of long term potentiation (LTP) and long term depression (LTD). Phosphorylation of GluA2 at serine 880 has been shown to disrupt interactions with the glutamate receptor interacting protein (GRIP), thus regulating receptor stability at the synapse.

Target alias

GluR2, GluA2

Immunogen

Peptide around phospho-serine 880

Specificity

The antibody recognizes the Glutamate Receptor 2-phosphoserine-880.

Clone ID

Glu2-p 880

Isotype

IgG

Preservative

None

Format

Lyophilized protein G purified in PBS pH7.4

Recommend starting dilution

If reconstituted with deionized water in 100 µl: WB 1:500-1:1000; ELISA 1:5000. Optimal dilution has to be determined by the user.

Limitations

Research Use Only

Storage

Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.