Glutamate is the main excitatory neurotransmitter in the mammalian central nervous system (CNS). Its receptors are either metabotropic or ionotropic. The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, also known as the AMPA receptor, is an ionotropic receptor made up of homomeric or heteromeric arrangments of Glutamate Receptor (GluR) subunits 1 to 4. GluR3 is one of the most common AMPA receptor in the CNS. The receptors are localized mainly post-synaptically and play important roles in the development and function of the nervous system. Autoimmunity to glutamate receptors may contribute to the pathology of some epilepsy syndromes.
GluR-3, Glutamate receptor 3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 100 µL: ELISA and FC: 5 µg / ml per sample. Optimal dilution has to be determined by the user.
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.