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Human ICAM-3 Mouse Monoclonal Antibody (MA4)

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Human ICAM-3 Mouse Monoclonal Antibody (MA4)

SKU:
MM-0199-P

USD 285.00 /100 µg

Clonality: 
Monoclonal
Host: Mouse
Reactivity: Human
Application: WB, FC

QTY:

OVERVIEW

Target: 
Human ICAM-3
Target background: 
Rapid clearing of apoptotic cells by phagocytes may prevent tissue damage. Studies show that ICAM-3 (also known as CD50), expressed on leukocytes, interacts with macrophages during apoptotic cell clearing (Torr et al., 2012). ICAM-3 plays an important role in the recruitment and tethering of macrophages during the process of clearing apoptotic human leukocytes, and ICAM-3 deficient cells have reduced clearance of apoptotic cells by phagocytes. This antibody, (MA4), has been shown to block the interaction of apoptotic leukocytes with macrophages/phagocytes.
Target alias: 
CD50, Intercellular adhesion molecule 3
Immunogen: 
Mammalian recombinant protein
Specificity: The antibody recognizes the domains 1-2 of intercellular adhesion molecule (ICAM)-3. This antibody has been shown to block the interaction of apoptotic leukocytes with macrophages/phagocytes.
Clone ID: 
MA4
Isotype: 
IgG1 kappa
Preservative: 
None
Format: 
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution: 
Reconstitute with deionized water. Optimal dilution has to be determined by the user.
Limitations: 
Research Use Only
Storage: 
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.