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Rat TNF-alpha ELISA Kit - 96 well

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Rat TNF-alpha ELISA Kit - 96 well

SKU:
455810

USD 594.00 /96 well microplate

QTY:

OVERVIEW

Target: 
Rat tumor necrosis factor-alpha
Target background: 
Rat tumor necrosis factor-alpha (TNF-α) is primarily a homotrimeric 17 kDa protein, a potent mediator of inflammatory and metabolic functions. Originally known as a highly cytotoxic cytokine for tumor cells, it is produced by lipopolysaccharide stimulated macrophages. When injected into tumor bearing animal, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further, TNF-α has been implied as central mediator in shock induced by gram negative microorganisms. TNF-α functions as a central mediator in many inflammatory and immunological processes. Interestingly, it also induced on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the p55 and p75 TNF-receptors. The receptors differ strongly in their intracellular signaling pathways.
Format: 
Kit
Limitations: 
See Supplier Webpage