MédiMabs Clones
A blog about science
Don’t let years of research depend on cryostorage 🥶
We all know that sudden wave of anxiety when a laboratory freezer alarm goes off over the weekend. For many labs, groundbreaking discoveries and years of hard work rely entirely on the survival of a few precious vials of hybridomas. Unfortunately, cell lines are not immortal—they can mutate, lose expression levels, become contaminated, or be […]
Beyond Irreversibility: Restoring the Brain’s Recycling Fleet to Combat Alzheimer’s Disease
While prior studies report NAD+ depletion in Alzheimer’s disease (AD) models and partial attenuation of pathology with NAD+ precursor supplementation (1), the “more is better” approach has its limits. High doses of NAD+ precursors can produce supraphysiologic levels that may promote cancer, making them a risky long-term solution. In a recent study in Cell Reports […]
When Brain Beavers Build Too Big: Breaking the Glycogen Dam in Tauopathy
In the complex landscape of neurodegenerative disorders like Alzheimer’s disease and frontotemporal lobar degeneration (FTLD), an interesting case of metabolic misbehavior has been identified by a research team at the Buck Institute of Research on Aging (1). Think of glycogen, the brain’s emergency energy reserve, as the building material. In affected neurons, the tau protein […]
