MM-0023

Presenilin 2 (C term) Mouse Monoclonal Antibody (APS21)

Application :

ELISA, IF, WB

Reactivity :

Human, Mouse, Rat

Host :

Mouse

Clonality :

Monoclonal

USD $305.00

/ 250 µg

Overview

Target

Presenilin 2 (C term)

Target background

Presenilin is an integral membrane protein ubiquitously expressed in the brain; it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1; PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

Target alias

PS-2, AD3LP, AD5, E5-1, STM-2, PSEN2

Immunogen

aa 34-45

Specificity

The antibody recognizes the C-terminal region of Presenilin 2 with no cross-reactivity observed with Presenilin 1.

Clone ID

APS21

Isotype

IgG1

Preservative

None

Format

Lyophilized protein free tissue culture supernatant

Recommend starting dilution

If reconstituted with deionized water in 250µL: ELISA 1:1000, WB 1:100, IF 1:1300, IHC 1:1300. Optimal dilution has to be determined by the user.

Limitations

Research Use Only

Storage

Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Product datasheet

Presenilin 2 (C term) Mouse Monoclonal Antibody (APS21)

SKU: MM-0023
250 µg

Overview

Target

Presenilin 2 (C term)

Target background

Presenilin is an integral membrane protein ubiquitously expressed in the brain; it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1; PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

Target alias

PS-2, AD3LP, AD5, E5-1, STM-2, PSEN2

Immunogen

aa 34-45

Specificity

The antibody recognizes the C-terminal region of Presenilin 2 with no cross-reactivity observed with Presenilin 1.

Clone ID

APS21

Isotype

IgG1

Preservative

None

Format

Lyophilized protein free tissue culture supernatant

Recommend starting dilution

If reconstituted with deionized water in 250µL: ELISA 1:1000, WB 1:100, IF 1:1300, IHC 1:1300. Optimal dilution has to be determined by the user.

Limitations

Research Use Only

Storage

Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.